Some iconic comments on HN include the interaction between cperciva and a Dropbox founder in 2007, celebrated for their perseverance (https://news.ycombinator.com/item?id=35079). Another notable thread features the humorous "Just the once, though, huh?" reply, highlighting a light-hearted moment. Additionally, references to curated lists like HN "highlights" and "bestcomments" showcase standout discussions.